Russell DeBose-Boyd (UTSW) 1: Feedback Regulation of HMG CoA Reductase October 11, 2019 6 By Ewald Bahringer CategoryArticles BlogTagscholesterol cholesterol homeostasis cholesterol regulation cholesterol synthesis endoplasmic reticulum associated degradation ER-associated degradation ERAD HMG CoA reductase ldl low-density lipoprotein Schnyder corneal dystrophy UBIAD1 6 Comments Manish Bishnoi says: October 9, 2019 at 7:10 pm Such a beautiful explanation . Reply ashwini702 says: October 9, 2019 at 8:04 pm As shown, statins inhibit the intracellular HMG CoA Reductase. That results in depletion of intracellular cholesterol synthesis. This in turn increases the uptake of circulatory LDL resulting in decrease in blood LDL level. So why does physicians advise testing blood cholesterol level when statin work intracellularly?? Secondly, as you said cells use either way of cholesterol synthesis and cholesterol accumulation is toxic, will the excess cholesterol from incoming LDL not become toxic? Reply Biomed Master says: October 9, 2019 at 8:46 pm This channel is a pure gold mine! <3 Such rich resource for life science students, professionals and enthousiasts! Reply TheFenerbahceSK says: October 10, 2019 at 4:13 am Would lipitor be an example of a statin? Reply Brainstorming Plus says: October 10, 2019 at 9:49 am Well done and keep it up! Reply KnowJesusKnowPeace says: October 11, 2019 at 3:12 am At 8:00, it is clear those studies all used very different risk groups. Otherwise, how could the placebo groups of all three other studies outperform the 4S treatment group? Reply Leave a Reply Cancel reply Your email address will not be published. Required fields are marked *Comment Name * Email * Save my name, email, and website in this browser for the next time I comment.