Why your digestive system needs rest (justification for daily fasting) | Ruth Patterson January 7, 2020 0 By Ewald Bahringer [Rhonda]: You know, we’ve been talking a lot about inflammation and these fasting blood glucose levels, fasting insulin. And it just hit, I remember having a conversation with Dr. Panda, and he mentioned something to me that I wasn’t aware of about repair mechanisms and fasting. I knew that repair mechanisms were regulated by the circadian rhythm, and I always knew that when you sleep is when you’re repairing a lot of damage. [Ruth]: Right. [Rhonda]: But it didn’t occur to me that also when you sleep is when you’re fasting. [Ruth]: Right. [Rhonda]: And he had mentioned that there’s something inherently important about fasting and repair mechanisms. And so, you know, which of course that kind of made me think, wow, that that’s really interesting, I never thought about it like that. But if you think about, you know, that the timing of these repair mechanisms and fasting and how, you’re repairing damaged, DNA repair mechanisms and also these autophagy, clearing away damaged cells, damaged cells secrete inflammatory mediators. So if you’re clearing away the cells that are damaged and secreting more, you know, inflammatory molecules, then possibly that would, you know, the lower the inflammation. But it’s really interesting how your data suggested that it really had to occur earlier in the evening. [Ruth]: Right. [Rhonda]: Do you have any speculation as to why that is? [Ruth]: Oh, I suppose we really do think that your body works best when its aligned with the circadian rhythm. But I think that is a really good observation. Certainly, the parallel I tend to think of is, you know, we work out, we actually hurt our muscles. And the muscles don’t repair and get stronger unless we stop. We have to stop, we have to give them a rest period. And the same thing, eating is metabolism, there’s a lot of oxidative damage that happens just as we eat. And then the theory is that you need a time off from that damage for the repair mechanisms to come in. So it’s an interesting observation in parallel. Personally, I don’t…I think that’s a little molecular for my research, but, yeah, I think it’s a good parallel to compare it with like working out. [Rhonda]: Yeah, that is, actually. You know, like you mentioned you need a repair time. Stress can activate stress response pathways that can be beneficial, like in the case of exercise. [Ruth]: Right. [Rhonda]: But if you keep on stressing yourself… [Ruth]: You actually get weaker. [Rhonda]: Right. There will… You know, repair. [inaudible 00:27:12] stress. [Ruth]: You do need to time off. [Rhonda]: Right. [Ruth]: Right. Exactly. CategoryArticlesTagsand breast cancer breast cancer risk cancer diabetes digestive health Dr. Rhonda Patrick Dr. Ruth Patterson fasting insulin intermittent fasting lifestyle meal frequency Ruth Patterson sleep that time restricted eating TRE weight you Leave a Reply Cancel reply Your email address will not be published. Required fields are marked *Comment Name * Email * Save my name, email, and website in this browser for the next time I comment.