Why your digestive system needs rest (justification for daily fasting) | Ruth Patterson

January 7, 2020 0 By Ewald Bahringer

[Rhonda]: You know, we’ve been talking a lot
about inflammation and these fasting blood glucose levels, fasting insulin. And it just hit, I remember having a conversation
with Dr. Panda, and he mentioned something to me that I wasn’t aware of about repair
mechanisms and fasting. I knew that repair mechanisms were regulated
by the circadian rhythm, and I always knew that when you sleep is when you’re repairing
a lot of damage. [Ruth]: Right. [Rhonda]: But it didn’t occur to me that also
when you sleep is when you’re fasting. [Ruth]: Right. [Rhonda]: And he had mentioned that there’s
something inherently important about fasting and repair mechanisms. And so, you know, which of course that kind
of made me think, wow, that that’s really interesting, I never thought about it like
that. But if you think about, you know, that the
timing of these repair mechanisms and fasting and how, you’re repairing damaged, DNA repair
mechanisms and also these autophagy, clearing away damaged cells, damaged cells secrete
inflammatory mediators. So if you’re clearing away the cells that
are damaged and secreting more, you know, inflammatory molecules, then possibly that
would, you know, the lower the inflammation. But it’s really interesting how your data
suggested that it really had to occur earlier in the evening. [Ruth]: Right. [Rhonda]: Do you have any speculation as to
why that is? [Ruth]: Oh, I suppose we really do think that
your body works best when its aligned with the circadian rhythm. But I think that is a really good observation. Certainly, the parallel I tend to think of
is, you know, we work out, we actually hurt our muscles. And the muscles don’t repair and get stronger
unless we stop. We have to stop, we have to give them a rest
period. And the same thing, eating is metabolism,
there’s a lot of oxidative damage that happens just as we eat. And then the theory is that you need a time
off from that damage for the repair mechanisms to come in. So it’s an interesting observation in parallel. Personally, I don’t…I think that’s a little
molecular for my research, but, yeah, I think it’s a good parallel to compare it with like
working out. [Rhonda]: Yeah, that is, actually. You know, like you mentioned you need a repair
time. Stress can activate stress response pathways
that can be beneficial, like in the case of exercise. [Ruth]: Right. [Rhonda]: But if you keep on stressing yourself… [Ruth]: You actually get weaker. [Rhonda]: Right. There will… You know, repair. [inaudible 00:27:12] stress. [Ruth]: You do need to time off. [Rhonda]: Right. [Ruth]: Right. Exactly.